In-silico and in-vitro study reveals ziprasidone as a potential aromatase inhibitor against breast carcinoma.

ABSTRACT: Aromatase enzyme plays a fundamental role in the development of estrogen receptors, and due to this functionality, the enzyme has gained significant attention as a therapeutic for reproductive disorders and cancer diseases. The currently employed aromatase inhibitors have severe side effects whereas our novel aromatase inhibitor is more selective and less toxic, therefore has greater potential to be developed as a drug. The research framework of this study is to identify a potent inhibitor for the aromatase target by profiling molecular descriptors of the ligand and to find a functional pocket in the target by docking and MD simulations. For assessing cellular and metabolic activities as indicators of cell viability and cytotoxicity, in-vitro studies were performed by using the colorimetri

SUBMITTER: Sahu A 

PROVIDER: S-EPMC10545834 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature