High-grade transformation of a polymorphous adenocarcinoma of the salivary gland: a case report and review of the literature.

ABSTRACT:

Background

Polymorphous adenocarcinoma (PAC) represents the second most widespread neoplasm of the minor salivary glands. These tumors rarely develop a histological progression from low-grade to high-grade malignancy, named "high-grade transformation" (HGT). Only nine cases are described in literature.

Case description

Here, we describe the case of a 76-year-old male patient with a PAC recurrence of the oral floor displaying HGT, and we explore the tumor cytomorphological features, genomic profiling, and the patient's clinical management. The tumor mass was characterized by poorly atypical cellular elements with vesicular nuclei and comedonecrosis foci. The growth pattern was predominantly solid, tubular, and cribriform. The lesion did not show microsatellite instability or

SUBMITTER: Miserocchi G 

PROVIDER: S-EPMC10545860 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature