Identification of human genetic variants modulating the course of COVID-19 infection with importance in other viral infections.

ABSTRACT: Introduction: COVID-19 has been a major focus of scientific research since early 2020. Due to its societal, economic, and clinical impact worldwide, research efforts aimed, among other questions, to address the effect of host genetics in susceptibility and severity of COVID-19. Methods: We, therefore, performed next-generation sequencing of coding and regulatory regions of 16 human genes, involved in maintenance of the immune system or encoding receptors for viral entry into the host cells, in a subset of 60 COVID-19 patients from the General Hospital Tešanj, Bosnia and Herzegovina, classified into three groups of clinical conditions of different severity ("mild," "moderate," and "severe"). Results: We confirmed that the male sex and older age are risk factors for seve

SUBMITTER: Salihefendic L 

PROVIDER: S-EPMC10545899 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature