GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses.

ABSTRACT:

Introduction

Gliomas have emerged as the predominant brain tumor type in recent decades, yet the exploration of non-apoptotic cell death regulated by the pan-optosome complex, known as pan-apoptosis, remains largely unexplored in this context. This study aims to illuminate the molecular properties of pan-apoptosis-related genes in glioma patients, classifying them and developing a signature using machine learning techniques.

Methods

The prognostic significance, mutation features, immunological characteristics, and pharmaceutical prediction performance of this signature were comprehensively investigated. Furthermore, GPX8, a gene of interest, was extensively examined for its prognostic value, immunological characteristics, medication prediction performance, and immunotherapy

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10545954 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature