Sleep disturbance, but not depression severity, is associated with inflammation in children and adolescents.

ABSTRACT:

Study objectives

We aimed to examine the association between self-rated and clinician-rated sleep disturbances and C-reactive protein (CRP), an objective marker of inflammation, in pediatric depression.

Methods

Two hundred fifty-six children and adolescents (15.2 ± 1.6 y, 72.3% female) with moderate to severe symptoms of depression participated in the study. Sleep disturbances were assessed by self-reports (Insomnia Severity Index) and clinician ratings (Kiddie-Schedule for Affective Disorder and Schizophrenia), inflammation by plasma CRP levels.

Results

Higher levels of CRP correlated positively with clinician-rated middle insomnia and hypersomnia. After adjusting for control variables (body mass index, tobacco, alcohol, stress, age, sex, antidepressants, sleep medic

SUBMITTER: Strumberger MA 

PROVIDER: S-EPMC10545993 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature