Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.

ABSTRACT: Migraine is a primary headache disorder recognized by the World Health Organization as one of the most poorly understood and debilitating neurological conditions impacting global disability. Chronic pain disorders are more frequently diagnosed among cisgender women than men, suggesting that female sex hormones could be responsible for mediating chronic pain, including migraine and/or that androgens can be protective. This review discusses the major gonadal hormones, estrogens, progesterone, and testosterone in the context of molecular mechanisms by which they play a role in migraine pathophysiology. In addition, the literature to date describing roles of minor sex hormones including prolactin, luteinizing hormone, follicular stimulating hormone, and gonadotropin releasing hormone in migrai

SUBMITTER: Martinez CI 

PROVIDER: S-EPMC10546064 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature