Routine breast milk monitoring using automated molecular assay system reduced postnatal CMV infection in preterm infants.

ABSTRACT: Human cytomegalovirus (CMV) transmitted through breast milk poses fatal risks to preterm infants. However, current molecular assay systems often do not accommodate breast milk samples. In this study, we evaluated the analytical and clinical performance of the measurement procedure of CMV load in breast milk utilizing the Cobas CMV test on the Cobas 6,800 system. This was enabled by incorporating a simple independent sample preparation procedure before the application of samples on the automated assay system. Clinical data from electronic medical records were retrospectively analyzed. Breast milk samples from mothers of preterm infants born before 33 weeks of gestation were screened for CMV using the automated assay system. CMV positivity rates in breast milk and neonatal samples and the CM

SUBMITTER: Song J 

PROVIDER: S-EPMC10546183 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature