Loneliness and Risk of Parkinson Disease.

ABSTRACT:

Importance

Loneliness is associated with morbidity and mortality, including higher risk of neurodegenerative diseases. To our knowledge, no study has examined whether the association between loneliness and detrimental outcomes extends to Parkinson disease (PD).

Objective

To assess whether loneliness is associated with risk of incident PD and whether the association is independent of other risk factors or modified by age, sex, and genetic vulnerability.

Design, setting, and participants

This prospective cohort study included a population-based sample of UK Biobank participants aged 38 to 73 years with loneliness data and without a diagnosis of PD at baseline who were first assessed from March 13, 2006, to October 1, 2010, and followed up to October 9, 2021.

Exposure

SUBMITTER: Terracciano A 

PROVIDER: S-EPMC10546293 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature