Nickel Catalyzed Carbonylation/Carboxylation Sequence via Double CO₂ Incorporation.

ABSTRACT: A carbonylation-carboxylation synthetic sequence, via double CO₂ fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl₃, triggered a cascade reaction with the formation of three consecutive C-C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl₃, and labeling (¹³CO₂) experiments validate the genuine incorporation of CO₂ in both functional groups.

SUBMITTER: Giovanelli R 

PROVIDER: S-EPMC10546374 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature