Mechanism of Shugan Yidan fan, a Chinese herbal formula, in rat model of premature ejaculation.

ABSTRACT:

Background

Premature ejaculation (PE) is one of the most common forms of sexual dysfunction in men, and multimodal therapeutic regimens should be considered to treat the condition. We developed a Chinese medicine herbal medicine, Shugan Yidan fang that had a significant clinical effect on PE patients, extending the time between penetration and ejaculation. However, the mechanism of this formula remains unclear. There is evidence that PE is associated with peripheral neuropathology, and the actions of dopamine (DA) and 5-hydroxytryptamine (5-HT). The aim of this study was to investigate the mechanism of Shugan Yidan fang's effect on PE through the relationship between sexual behavioristics and the level of neurotransmitters and dopamine receptors (DARs).

Results

We showed tha

SUBMITTER: Han Q 

PROVIDER: S-EPMC10546682 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature