Epigenomic response to albuterol treatment in asthma-relevant airway epithelial cells.

ABSTRACT:

Background

Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuterol could induce changes in the airway epithelial methylome. We aimed to characterize albuterol-induced DNAm changes in airway epithelial cells, and assess potential functional consequences and the influence of genetic variation and asthma-related clinical variables.

Results

We followed a discovery and validation study design to characterize albuterol-induced DNAm changes in paired airway epithelial cultures stimulated in vitro with albuterol. In the discovery phase, an epigenome-wide association study using paired nasal epithelial culture

SUBMITTER: Perez-Garcia J 

PROVIDER: S-EPMC10546710 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature