The role of apheresis and insulin therapy in hypertriglyceridemic acute pancreatitis-a concise review.

ABSTRACT: Severe hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP) and is involved in its pathogenesis. Chylomicrons increase blood viscosity and induce ischemia, while free fatty acids induce inflammation and distant organ damage. Conservative treatment options include fasting and insulin; limited evidence shows their comparable efficacy. Plasma exchange might provide more rapid lowering of triglycerides and amelioration of systemic effects of severe AP. Available data from controlled studies show only moderately faster lowering of triglycerides with apheresis (about 70% vs. 50% with conservative treatment within 24 h) and limited data from non-randomized studies show no improvement in clinical outcomes. New evidence is expected soon from ongoing large randomized

SUBMITTER: Gubensek J 

PROVIDER: S-EPMC10546782 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature