<i>In vitro</i> activity of cefiderocol against <i>Pseudomonas aeruginosa</i> demonstrating evolved resistance to novel β-lactam/β-lactamase inhibitors.

ABSTRACT:

Background

Cefiderocol demonstrates excellent activity against MDR Pseudomonas aeruginosa; however, the activity against isolates from patients previously treated with β-lactam agents is unknown. We aimed to determine the activity of cefiderocol against P. aeruginosa collected before and after treatment with traditional β-lactams and new β-lactam/β-lactamase inhibitors.

Methods

Cefiderocol MICs were determined in triplicate in iron-depleted cation-adjusted Mueller-Hinton broth and compared with β-lactam MICs tested by standard methods. All isolates underwent WGS analysis to identify mutations associated with resistance.

Results

One hundred and seventy-eight P. aeruginosa isolates were evaluated; 48% (86/178) were non-susceptible to ceftazidime/avi

SUBMITTER: Shields RK 

PROVIDER: S-EPMC10546814 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature