Correlation Between Fundus Autofluorescence Pattern and Retinal Function on Microperimetry in Choroideremia.

ABSTRACT:

Purpose

In patients with choroideremia, it is not known how smooth and mottled patterns on short-wavelength fundus autofluorescence (AF) imaging relate to retinal function.

Methods

A retrospective case-note review was undertaken on 190 patients with choroideremia at two specialist centers for retinal genetics. Twenty patients with both smooth and mottled zones on short-wavelength AF imaging and concurrent mesopic microperimetry assessments were included. Mean retinal sensitivities within the smooth and mottled zones were compared between choroideremia patients, and identical points on mesopic microperimetry collected from 12 age-matched controls. Longitudinal analyses were undertaken at 2 and 5 years in a subset of patients.

Results

In patients with choroideremia, mea

SUBMITTER: Poli FE 

PROVIDER: S-EPMC10547012 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature