Choroidal Changes in Rhesus Macaques in Aging and Age-Related Drusen.

ABSTRACT:

Purpose

Choroidal vascular changes occur with normal aging and age-related macular degeneration (AMD). Here, we evaluate choroidal thickness and vascularity in aged rhesus macaques to better understand the choroid's role in this nonhuman primate model of AMD.

Methods

We analyzed optical coherence tomography (OCT) images of 244 eyes from 122 rhesus macaques (aged 4-32 years) to measure choroidal thickness (CT) and choroidal vascularity index (CVI). Drusen number, size, and volume were measured by semiautomated annotation and segmentation of OCT images. We performed regression analyses to determine any association of CT or CVI with age, sex, and axial length and to determine if the presence and volume of soft drusen impacted these choroidal parameters.

Results

In rhesus

SUBMITTER: Sazhnyev Y 

PROVIDER: S-EPMC10547013 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature