Evaluating power to detect recurrent selective sweeps under increasingly realistic evolutionary null models.

ABSTRACT: The detection of selective sweeps from population genomic data often relies on the premise that the beneficial mutations in question have fixed very near the sampling time. As it has been previously shown that the power to detect a selective sweep is strongly dependent on the time since fixation as well as the strength of selection, it is naturally the case that strong, recent sweeps leave the strongest signatures. However, the biological reality is that beneficial mutations enter populations at a rate, one that partially determines the mean wait time between sweep events and hence their age distribution. An important question thus remains about the power to detect recurrent selective sweeps when they are modeled by a realistic mutation rate and as part of a realistic distribution of fitne

SUBMITTER: Soni V 

PROVIDER: S-EPMC10547124 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature