Diffusion-enhanced characterization of 3D chromatin structure reveals its linkage to gene regulatory networks and the interactome.

ABSTRACT: The interactome networks at the DNA, RNA, and protein levels are crucial for cellular functions, and the diverse variations of these networks are heavily involved in the establishment of different cell states. We have developed a diffusion-based method, Hi-C to geometry (C_TG), to obtain reliable geometric information on the chromatin from Hi-C data. C_TG produces a consistent and reproducible framework for the 3D genomic structure and provides a reliable and quantitative understanding of the alterations of genomic structures under different cellular conditions. The genomic structure yielded by C_TG serves as an architectural blueprint of the dynamic gene regulatory network, based on which cell-specific correspondence between gene-gene and corresponding protei

SUBMITTER: He Y 

PROVIDER: S-EPMC10547250 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature