Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development.

ABSTRACT: Background Endocardial cells are a major progenitor population that gives rise to heart valves through endocardial cushion formation by endocardial to mesenchymal transformation and the subsequent endocardial cushion remodeling. Genetic variants that affect these developmental processes can lead to congenital heart valve defects. Crk and Crkl are ubiquitously expressed genes encoding cytoplasmic adaptors essential for cell signaling. This study aims to explore the specific role of Crk and Crkl in the endocardial lineage during heart valve development. Methods and Results We deleted Crk and Crkl specifically in the endocardial lineage. The resultant heart valve morphology was evaluated by histological analysis, and the underlying cellular and molecu

SUBMITTER: Wu B 

PROVIDER: S-EPMC10547300 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature