Total and Regional Fat/Muscle Mass Ratio and Risks of Incident Cardiovascular Disease and Mortality.

ABSTRACT: Background To evaluate the sex-specific associations of total and regional fat/muscle mass ratio (FMR) with cardiovascular disease (CVD) incidence and mortality, and to explore the underlying mechanisms driven by cardiometabolites and inflammatory cells. We compared the predictive value of FMRs to body mass index. Methods and Results This population-based, prospective cohort study included 468 885 UK Biobank participants free of CVD at baseline. Fat mass and muscle mass were estimated using a bioelectrical impedance assessment device. FMR was calculated as fat mass divided by muscle mass in corresponding body parts (total body, trunk, arm, and leg). Multivariable Cox proportional hazards models and mediation analyses were used. During 12.5 years of follow-up, we documented 49 936 CVD cases

SUBMITTER: Zhou R 

PROVIDER: S-EPMC10547339 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature