Effect of Cardiopulmonary Bypass on SARS-CoV-2 Vaccination Antibody Levels.

ABSTRACT: Background Adults undergoing heart surgery are particularly vulnerable to respiratory complications, including COVID-19. Immunization can significantly reduce this risk; however, the effect of cardiopulmonary bypass (CPB) on immunization status is unknown. We sought to evaluate the effect of CPB on COVID-19 vaccination antibody concentration after cardiac surgery. Methods and Results This prospective observational clinical trial evaluated adult participants undergoing cardiac surgery requiring CPB at a single institution. All participants received a full primary COVID-19 vaccination series before CPB. SARS-CoV-2 spike protein-specific antibody concentrations were measured before CPB (pre-CPB measurement), 24 hours following CPB (postoperative day 1 measurement), and approximately 1 month f

SUBMITTER: Strobel RJ 

PROVIDER: S-EPMC10547352 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature