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Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort.

ABSTRACT:

Background

Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor.

Methods

In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains.

Results

Collectively, both ribonucleic acid and deoxyribonucleic acid viruses were negatively associated with RotaTeq shedding (adjusted odds ratio = 0.29, 95% confidence interval = 0.14-0.58 and adjusted odds ratio = 0.30, 95% confidence interval = 0.11-0.78, respectively).

Conclusions

Enteric viruses may interfere with RotaTeq replication in the gut and thus RotaTeq stool shedding.

SUBMITTER: El-Heneidy A

PROVIDER: S-EPMC10547457 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Interference Between Enteric Viruses and Live-Attenuated Rotavirus Vaccine Virus in a Healthy Australian Birth Cohort.

El-Heneidy Asmaa A Grimwood Keith K Lambert Stephen B SB Ware Robert S RS

The Journal of infectious diseases 20231001 7

<h4>Background</h4>Rotavirus vaccines have reduced effectiveness in high-mortality settings. Interference between enteric viruses and live-attenuated oral vaccine strains may be a factor.<h4>Methods</h4>In a birth cohort of healthy Australian infants, parents collected weekly stool samples. Three hundred eighty-one paired swabs collected within 10-days of RotaTeq vaccination from 140 infants were tested for 10 enteric viruses and RotaTeq strains.<h4>Results</h4>Collectively, both ribonucleic aci ...[more]

PMID: 37014728

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