Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1.
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ABSTRACT:
SUBMITTER: Fang H
PROVIDER: S-EPMC10547475 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1.
Fang Huan H Ren Wenlong W Cui Qiuxia Q Liang Huichun H Yang Chuanyu C Liu Wenjing W Wang Xinye X Liu Xue X Shi Yujie Y Feng Jing J Chen Ceshi C
eLife 20231003
Anti-tumor drug resistance is a challenge for human triple-negative breast cancer (TNBC) treatment. Our previous work demonstrated that TNFAIP2 activates RAC1 to promote TNBC cell proliferation and migration. However, the mechanism by which TNFAIP2 activates RAC1 is unknown. In this study, we found that TNFAIP2 interacts with IQGAP1 and Integrin β4. Integrin β4 activates RAC1 through TNFAIP2 and IQGAP1 and confers DNA damage-related drug resistance in TNBC. These results indicate that the Integr ...[more]
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