FDG-PET/CT discriminates between patients with and without lymphomas in primary Sjogren's syndrome.

ABSTRACT:

Objectives

To assess the usefulness of [18F]-fluorodeoxyglucose (FDG)-PET/CT (i) to discriminate between primary SS (pSS) patients with and without lymphomas and (ii) to evaluate systemic disease activity in pSS.

Methods

ACR-EULAR-positive pSS patients who underwent FDG-PET/CT were included. Scans were visually evaluated and quantitative analysis was performed by measuring standardized uptake values (SUV) of salivary and lacrimal glands and systemic regions. Receiver operating characteristic curve analyses were performed to find SUV cut-off values to discriminate between lymphoma and non-lymphoma.

Results

Of the 70 included patients, 26 were diagnosed with a pSS-associated lymphoma, mostly of the mucosa-associated lymphoid tissue type (23/26). Lymphoma patients showed

SUBMITTER: van Ginkel MS 

PROVIDER: S-EPMC10547509 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature