Association between Taql polymorphism of vitamin D receptor gene and vertical growth of the mandible: A cross-sectional study.

ABSTRACT:

Objective

To determine whether the gonial angle on digital panoramic radiographs is associated with vitamin D receptor (VDR) Taql polymorphism.

Methods

Genomic DNA samples were collected from the buccal mucosa of patients aged 26-43 years. TaqMan assay for single nucleotide polymorphism genotyping was used to detect the genotype of Taql polymorphism. The gonial angle was measured bilaterally on panoramic radiography. The normal gonial angle was fixed as 121.8°, and it represented the cutoff value for the high gonial angle (HGA) and low gonial angle (LGA) groups. Various genetic models were analyzed, namely dominant (homozygous [AA] vs. heterozygous [AG] + polymorphic [GG]), recessive (AA + AG vs. GG), and additive (AA + GG vs. AG), using the chi-squared test.

Resul

SUBMITTER: Telatar BC 

PROVIDER: S-EPMC10547590 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature