Is the One-Compartment Model with First Order Absorption a Useful Approximation?

ABSTRACT:

Purpose

The one-compartment model with first order absorption (ka1C) has been extensively used to fit oral data. But when the disposition parameters of the drug are not available, the bias in the parameter estimates remains unclear. In this paper, the effect of potential misspecification of the area under the curve (AUC) and the mean absorption time (MAT) was evaluated for three relatively slowly absorbed drugs/formulations.

Methods

Assuming a three-compartment disposition model with an input (absorption) rate described as a sum of two inverse Gaussian functions (2IG3C) as the true model, the deviations of AUC and MAT estimated with simpler models were analyzed. Simpler models, as the ka1C model (Bateman function), the one-compartment model with IG input function (IG1C) and

SUBMITTER: Weiss M 

PROVIDER: S-EPMC10547630 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature