Can physiologic colonic [¹⁸F]FDG uptake in PET/CT imaging predict response to immunotherapy in metastatic melanoma?

ABSTRACT:

Aim

The development of biomarkers that can reliably and early predict response to immune checkpoint inhibitors (ICIs) is crucial in melanoma. In recent years, the gut microbiome has emerged as an important regulator of immunotherapy response, which may, moreover, serve as a surrogate marker and prognosticator in oncological patients under immunotherapy. Aim of the present study is to investigate if physiologic colonic [¹⁸F]FDG uptake in PET/CT before start of ICIs correlates with clinical outcome of metastatic melanoma patients. The relation between [¹⁸F]FDG uptake in lymphoid cell-rich organs and long-term patient outcome is also assessed.

Methodology

One hundred nineteen stage IV melanoma patients scheduled for immunotherapy with ipilimumab, applied e

SUBMITTER: Sachpekidis C 

PROVIDER: S-EPMC10547632 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature