Early biochemical and radiographic response after one cycle of [¹⁷⁷Lu]Lu-PSMA I&T radioligand therapy in metastatic castration-resistant prostate cancer patients.

ABSTRACT:

Purpose

The aim of this study was to investigate very early radiographic PSMA PET response after one cycle of [¹⁷⁷Lu]Lu-PSMA I&T radioligand therapy (RLT) of metastatic castration-resistant prostate cancer (mCRPC) and to assess its role in predicting overall response and survival.

Methods

This retrospective study enrolled 40 mCRPC patients who were treated with a median of 3 (2-9) [¹⁷⁷Lu]Lu-PSMA I&T RLT cycles. Biochemical response was based on the relative change of serum PSA according to PCWG3 criteria, while radiographic response referred to the relative change of PSMA-derived total viable tumor volumes expressed as total lesion PSMA (TLP).

Results

After one cycle of RLT, biochemical partial response (PR) was seen in 8/40 (20.0%), stable disea

SUBMITTER: Cytawa W 

PROVIDER: S-EPMC10547638 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature