Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.

ABSTRACT:

Background

Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International Association for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is significantly associated with favorable outcome. However, since symptoms of LC at early stages are unspecific and resemble those of benign pathologies, current diagnostic approaches are mostly initiated at advanced LC stages.

Methods

We developed a LC diagnosis test based on the analysis of distinct RNA isoforms expressed from the GATA6 and NKX2-1 gene loci, which are detected in exhaled br

SUBMITTER: Rubio K 

PROVIDER: S-EPMC10547665 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature