Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways.

ABSTRACT: Pseudospondias microcarpa is used in ethnomedicine to manage central nervous system diseases. The hydroethanolic extract (PME) from the leaves of the plant has shown anxiolytic-like properties in mice anxiety models. However, its effects in chronic anxiety models and possible mechanism(s) of action were not studied. Therefore, the current study evaluated the anxiolytic-like mechanisms of PME in zebrafish models of anxiety. The zebrafish light dark test (LDT) and novel tank test (NTT) were employed to assess the anxiolytic-like effects of PME (0.1, 0.3, 1.0 mg mL^-1), fluoxetine (3 × 10^-5 mg mL^-1) and diazepam (1.5 × 10^-7 mg mL^-1). The chronic unpredictable stress (CUS) test was used to further evaluate the extract's anxiolytic-like prop

SUBMITTER: Adongo DW 

PROVIDER: S-EPMC10547670 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature