Baseline heart rate variability predicts placebo hypoalgesia in men, but not women.

ABSTRACT:

Introduction

Placebo hypoalgesic effects vary greatly across individuals, making them challenging to control for in clinical trials and difficult to use in treatment. We investigated the potential of resting vagally-mediated heart rate variability (vmHRV) to help predict the magnitude of placebo responsiveness.

Methods

In two independent studies (total N = 77), we administered a placebo paradigm after measuring baseline HRV. In Study I, we delivered heat pain to the forearm, on skin patches treated with "real" and "control" cream (identical inactive creams). In Study II, electrical pulses to the forearm were modulated by sham transcutaneous electrical nerve stimulation. We combined data from both studies to evaluate the relationship between vagally-mediated HRV (vmHRV

SUBMITTER: Krecke J 

PROVIDER: S-EPMC10547887 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature