Immuno-metabolic signaling in leishmaniasis: insights gained from mathematical modeling.

ABSTRACT:

Motivation

Leishmaniasis is a global concern especially in underdeveloped and developing subtropical and tropical regions. The extent of infectivity in host is majorly dependent on functional polarization of macrophages. Classically activated M1 macrophage can eliminate parasite through production of iNOS and alternatively activated M2 macrophages can promote parasite growth through by providing shelter and nutrients to parasite. The biological processes involved in immune signaling and metabolism of host and parasite might be responsible for deciding fate of parasite.

Results

Using systems biology approach, we constructed two mathematical models and inter-regulatory immune-metabolic networks of M1 and M2 state, through which we identified crucial components that are associa

SUBMITTER: Khandibharad S 

PROVIDER: S-EPMC10548086 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature