Interleukin-17 producing cells in swine induced by microbiota during the early postnatal period - a brief research report.

ABSTRACT: Interleukin-17A (IL-17) is a pro-inflammatory cytokine involved in the immune response to many pathogens playing also a role in certain chronic and autoimmune diseases. The presented study focused on the early postnatal development of IL-17 producing cells in swine. In agreement with previous studies, αβ T-helper (CD3⁺CD4⁺) and γδ T (CD3⁺TCRγδ⁺) cells were found to be the major producers of IL-17. In newborn conventional piglets, αβ T-helper cells positive for IL-17 were almost undetectable, but their frequency increased markedly with age in all issues examined, i.e., blood, spleen, and mesenteric lymph nodes (MLN). Additional analyses of CD8 and CD27 expression showed that the main αβ T-helper producers of IL-17 has CD8⁺CD27^-

SUBMITTER: Stepanova H 

PROVIDER: S-EPMC10548118 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature