Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study.

ABSTRACT: Although obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promisi

SUBMITTER: Antkowiak M 

PROVIDER: S-EPMC10548226 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature