Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.

ABSTRACT:

Background and aims

Intestinal epithelial cells separate the luminal flora from lamina propria immune cells and regulate innate immune responses in the gut. An imbalance of the mucosal immune response and disrupted intestinal barrier integrity contribute to the evolution of inflammatory bowel diseases. Interleukin (IL)-37 has broad anti- inflammatory activity and is expressed by the human intestinal epithelium. Mice ectopically expressing human IL-37 show reduced epithelial damage and inflammation after DSS-induced colitis. Here, we investigated the impact of IL-37 on the innate immune response and tight junction protein expression of mouse intestinal organoids and the modulation of IL37 expression in human intestinal organoids.

Methods

Murine intestinal organoids wer

SUBMITTER: Krohn L 

PROVIDER: S-EPMC10548260 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature