Remote Ischemic Conditioning for Acute Stroke: The RESIST Randomized Clinical Trial.

ABSTRACT:

Importance

Despite some promising preclinical and clinical data, it remains uncertain whether remote ischemic conditioning (RIC) with transient cycles of limb ischemia and reperfusion is an effective treatment for acute stroke.

Objective

To evaluate the effect of RIC when initiated in the prehospital setting and continued in the hospital on functional outcome in patients with acute stroke.

Design, setting, and participants

This was a randomized clinical trial conducted at 4 stroke centers in Denmark that included 1500 patients with prehospital stroke symptoms for less than 4 hours (enrolled March 16, 2018, to November 11, 2022; final follow-up, February 3, 2023).

Intervention

The intervention was delivered using an inflatable cuff on 1 upper extremity (RIC cuff

SUBMITTER: Blauenfeldt RA 

PROVIDER: S-EPMC10548297 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature