Association of Medication Adherence With Health Outcomes in the ISCHEMIA Trial.

ABSTRACT:

Background

The ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial randomized participants with chronic coronary disease (CCD) to guideline-directed medical therapy with or without angiography and revascularization. The study examined the association of nonadherence with health status outcomes.

Objectives

The study sought to compare 12-month health status outcomes of adherent and nonadherent participants with CCD with an a priori hypothesis that nonadherent patients would have better health status if randomized to invasive management.

Methods

Self-reported medication-taking behavior was assessed at randomization with a modified 4-item Morisky-Green-Levine Adherence Scale, and participants were classified as adh

SUBMITTER: Garcia RA 

PROVIDER: S-EPMC10548342 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature