Highly regioselective oxidation of C-H bonds in water using hydrogen peroxide by a cytochrome P450 mimicking iron complex.

ABSTRACT: Cytochrome P450, one of nature's oxidative workhorses, catalyzes the oxidation of C-H bonds in complex biological settings. Extensive research has been conducted over the past five decades to develop a fully functional mimic that activates O₂ or H₂O₂ in water to oxidize strong C-H bonds. We report the first example of a synthetic iron complex that functionally mimics cytochrome P450 in 100% water using H₂O₂ as the oxidant. This iron complex, in which one methyl group is replaced with a phenyl group in either wing of the macrocycle, oxidized unactivated C-H bonds in small organic molecules with very high selectivity in water (pH 8.5). Several substrates (34 examples) that contained arenes, heteroaromatics, and polar functional groups we

SUBMITTER: Jana S 

PROVIDER: S-EPMC10548533 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature