Modelling mass drug administration strategies for reducing scabies burden in Monrovia, Liberia.

ABSTRACT: Scabies is a parasitic infestation with high global burden. Mass drug administrations (MDAs) are recommended for communities with a scabies prevalence of >10%. Quantitative analyses are needed to demonstrate the likely effectiveness of MDA recommendations. In this study, we developed an agent-based model of scabies transmission calibrated to demographic and epidemiological data from Monrovia. We used this model to compare the effectiveness of MDA scenarios for achieving scabies elimination and reducing scabies burden, as measured by time until recrudescence following delivery of an MDA and disability-adjusted-life-years (DALYs) averted. Our model showed that three rounds of MDA delivered at six-month intervals and reaching 80% of the population could reduce prevalence below 2% for three ye

SUBMITTER: Tellioglu N 

PROVIDER: S-EPMC10548539 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature