Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress.

ABSTRACT:

Background

Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer's disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction have been implicated in CAA but the cellular source of reactive oxygen species (ROS) and related signaling mechanisms remain unclear. We tested the hypothesis that brain border-associated macrophages (BAM), yolk sac-derived myeloid cells closely apposed to parenchymal and leptomeningeal blood vessels, are the source of radicals through the Aβ-binding innate immunity receptor CD36, leading to neurovascular dysfunction, CAA, and cognitive impairment.

Methods

Tg2576 mice and WT littermates were transplanted with CD36^-/- or CD36^+/+ bone marrow

SUBMITTER: Uekawa K 

PROVIDER: S-EPMC10548599 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature