Proteomic profiling identifies novel inflammation-related plasma proteins associated with ischemic stroke outcome.

ABSTRACT:

Background

The inflammatory response to cerebral ischemia is complex; however, most clinical studies of stroke outcome focus on a few selected proteins. We, therefore, aimed to profile a broad range of inflammation-related proteins to: identify proteins associated with ischemic stroke outcome that are independent of established clinical predictors; identify proteins subsets for outcome prediction; and perform sex and etiological subtype stratified analyses.

Methods

Acute-phase plasma levels of 65 inflammation-related proteins were measured in 534 ischemic stroke cases. Logistic regression was used to estimate associations to unfavorable 3-month functional outcome (modified Rankin Scale score > 2) and LASSO regressions to identify proteins with independent effects.

Results

SUBMITTER: Angerfors A 

PROVIDER: S-EPMC10548608 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature