In vivo cortical diffusion imaging relates to Alzheimer's disease neuropathology.

ABSTRACT:

Background

There has been increasing interest in cortical microstructure as a complementary and earlier measure of neurodegeneration than macrostructural atrophy, but few papers have related cortical diffusion imaging to post-mortem neuropathology. This study aimed to characterise the associations between the main Alzheimer's disease (AD) neuropathological hallmarks and multiple cortical microstructural measures from in vivo diffusion MRI. Comorbidities and co-pathologies were also investigated.

Methods

Forty-three autopsy cases (8 cognitively normal, 9 mild cognitive impairment, 26 AD) from the National Alzheimer's Coordinating Center and Alzheimer's Disease Neuroimaging Initiative databases were included. Structural and diffusion MRI scans were analysed to calculate cortic

SUBMITTER: Torso M 

PROVIDER: S-EPMC10548768 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature