Systematic Review of Protein Biomarkers in Adult Patients With Chronic Rhinosinusitis.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is a heterogeneous condition characterized by differing inflammatory endotypes. The identification of suitable biomarkers could enable personalized approaches to treatment selection.

Objective

This study aimed to identify and summarize clinical studies of biomarkers in adults with CRS in order to inform future research into CRS endotypes.

Methods

We conducted systematic searches of MEDLINE and Web of Science from inception to January 30, 2022 and included all clinical studies of adult CRS patients and healthy controls measuring biomarkers using enzyme-linked immunosorbent assays or Luminex immunoassays. Outcomes included the name and tissue type of identified biomarkers and expression patterns within CRS phenotypes. Study qualit

SUBMITTER: Gokani SA 

PROVIDER: S-EPMC10548774 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature