Long-term Effects of Gastric Acid Prophylaxis in Kidney Transplant Recipients.

ABSTRACT:

Objectives

Prophylactic acid suppression with proton pump inhibitors or H2 receptor antagonists is often administered after kidney transplantation. The Association of proton pump inhibitors or H2 receptor antagonists with acute rejection, hypomagnesemia, and graft loss in kidney transplant recipients is not well established.

Material and methods

We performed a retrospective cohort study of 302 kidney transplant recipients at one center (57% male; mean age 35.5±11.2 years) with more than 6 months post-transplant follow-up. Recipients were grouped according to gastric acid prophylaxis: only proton pump inhibitors (n=179), only H2 receptor antagonists (n=42), proton pump inhibitors and H2 receptor antagonists (n=55), and nonusers (n=26). The primary outcome was biopsy-proven ac

SUBMITTER: Yazici H 

PROVIDER: S-EPMC10548784 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature