A systematic review and meta-analysis of neopterin in rheumatic diseases.

ABSTRACT:

Introduction

Novel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs). We assessed the available evidence regarding the pathophysiological role of neopterin, the oxidation product of 7,8-dihydroneopterin, a pteridine generated in macrophages activated by interferon-γ, by conducting a systematic review and meta-analysis of studies reporting its concentrations in biological fluids in RD patients and healthy controls.

Methods

We searched electronic databases for relevant articles published between inception and 31 August 2023. The risk of bias and the certainty of evidence were assessed using the Joanna Briggs Institute Critical Appraisal Checklist and the Grades of Rec

SUBMITTER: Mangoni AA 

PROVIDER: S-EPMC10548830 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature