Identification of distinct gene co-expression modules and specific hub genes in skin lesions of atopic dermatitis and psoriasis by WGCNA.

ABSTRACT: Atopic dermatitis (AD) and psoriasis are among the most common chronic inflammatory skin diseases. Although AD and psoriasis are distinguished using clinical criteria, the lesions of these two diseases are sometimes highly similar, making diagnosis difficult. In addition, the mechanisms underlying these two diseases are not fully clear. Here, we aimed to identify potential genes and regulatory mechanisms in AD and psoriasis patients to aid in the diagnosis and treatment of AD and psoriasis. The GSE121212 dataset was obtained from the NCBI Gene Expression Omnibus database and weighted gene co-expression network analysis (WGCNA) was applied. The functions of genes in modules of interest were determined using Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes analys

SUBMITTER: Sheng Y 

PROVIDER: S-EPMC10549218 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature