Inhibition of vascular endothelial growth factor-A downregulates angiogenesis in psoriasis: A pilot study.

ABSTRACT:

Background

Vascular Endothelial Growth Factor (VEGF)-A-mediated angiogenesis participates in the pathogenesis of psoriasis, thus inviting the hypothesis that anti-VEGF-A therapy could be beneficial in psoriasis. While anti-angiogenic agents are used in oncology and ophthalmology, these therapeutic strategies remain unexplored for the management of psoriasis.

Objective

Our objective was to investigate ex vivo how VEGF-A blockade impacts blood vessels, epidermis and immune cells in organ-cultured plaque and non-lesional skin from patients with psoriasis.

Methods

Skin biopsies from patients with psoriasis (n = 6; plaque and non-lesional skin) and healthy controls (n = 6) were incubated with anti-VEGF-A monoclonal antibody (bevacizumab, Avastin®) or a human

SUBMITTER: Luengas-Martinez A 

PROVIDER: S-EPMC10549813 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature