Multi-omics investigation of the resistance mechanisms of pomalidomide in multiple myeloma.

ABSTRACT:

Background

Despite significant therapeutic advances over the last decade, multiple myeloma remains an incurable disease. Pomalidomide is the third Immunomodulatory drug that is commonly used to treat patients with relapsed/refractory multiple myeloma. However, approximately half of the patients exhibit resistance to pomalidomide treatment. While previous studies have identified Cereblon as a primary target of Immunomodulatory drugs' anti-myeloma activity, it is crucial to explore additional mechanisms that are currently less understood.

Methods

To comprehensively investigate the mechanisms of drug resistance, we conducted integrated proteomic and metabonomic analyses of 12 plasma samples from multiple myeloma patients who had varying responses to pomalidomide. Differentially

SUBMITTER: Zhuang Y 

PROVIDER: S-EPMC10549987 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature