Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism.

ABSTRACT: Children with autism spectrum disorders (ASDs) often display atypical learning styles; however, little is known regarding learning-related brain plasticity and its relation to clinical phenotypic features. Here, we investigate cognitive learning and neural plasticity using functional brain imaging and a novel numerical problem-solving training protocol. Children with ASD showed comparable learning relative to typically developing children but were less likely to shift from rule-based to memory-based strategy. While learning gains in typically developing children were associated with greater plasticity of neural representations in the medial temporal lobe and intraparietal sulcus, learning in children with ASD was associated with more stable neural representations. Crucially, the relation b

SUBMITTER: Liu J 

PROVIDER: S-EPMC10550286 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature