Short-term and repeated exposure to particulate matter sizes from Imperial Valley, California to induce inflammation and asthmatic-like symptoms in mice.

ABSTRACT: Imperial Valley, California has become increasingly hot, dry, and polluted over the past decade. Particulate matter (PM) levels are amongst the highest in this State, associated with significantly higher asthma prevalence among children in the region compared to national and state averages. The present study was performed to test the hypothesis that Imperial Valley PM by size and chemical composition might possess allergenic properties following introduction into murine lungs without prior sensitization to a known allergen with size fraction as a determining factor. In acute exposure experiments, BALB/c male mice were administered a single 50-μl oropharyngeal aspiration of nanopure water (H₂O; control) or a stock 1 μg/μl PM solution. In sub-acute exposure experiments, male and f

SUBMITTER: D'Evelyn SM 

PROVIDER: S-EPMC10550522 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature