Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies.

ABSTRACT:

Background

In patients with idiopathic inflammatory myopathies (IIM), autoantibodies are associated with specific clinical phenotypes suggesting a pathogenic role of adaptive immunity. We explored if autoantibody profiles are associated with specific HLA genetic variants and clinical manifestations in IIM.

Methods

We included 1348 IIM patients and determined the occurrence of 14 myositis-specific or -associated autoantibodies. We used unsupervised cluster analysis to identify autoantibody-defined subgroups and logistic regression to estimate associations with clinical manifestations, HLA-DRB1, HLA-DQA1, HLA-DQB1 alleles, and amino acids imputed from genetic information of HLA class II and I molecules.

Findings

We identified eight subgroups with the following dominant

SUBMITTER: Leclair V 

PROVIDER: S-EPMC10550566 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature